Northwestern University Feinberg School of Medicine

Department of Surgery

(2017-2019) - MENTOR: Jason Wertheim, MD

Vascular disease—including narrowing and occlusion of blood vessels that deliver oxygen and nutrients to the heart, vital organs and extremities—inflicts a significant public health burden for which improved methodologies to model disease, develop therapeutics, and design new interventions to alleviate disease may provide symptomatic relief and improve function. Dr. Hekman's project focuses on overcoming a major limitation in the development of patient-derived endothelial cells using induced pluripotent stem cell technology. This technology is currently limited by reprogramming-induced senescence whereby the mature cellular phenotype degenerates and is lost. She will work to overcome this barrier to generate functional patient-derived endothelial cells for clinical and therapeutic applications. She is a post-doctoral fellow supported by an F32 Ruth L. Kirschstein NRSA individual post-doctoral fellowship award from NHLBI.

Publications

K Hekman, M Wohlauer, G Magee, A Lee, C Shokrzadeh, C Carsten, R Chaer, N Singh, K Brown, D Coleman. Perspectives and Perceived Needs of the Contemporary Vascular Surgery Trainee: Results of the National APDVS Trainee Survey. Manuscript in preparation.

Hekman KE, Michel E, Blay E Jr., Helenowski IB, Yang AD, Hoel AW. Evaluation of the Effectiveness of an Evidence-Based Bundled Quality Improvement Intervention in Reducing Surgical Site Infections in Lower Extremity Vascular Bypass Procedures. Manuscript in preparation.

Mansukhani NA, Hekman KE, Yoon DY, Hoel AW, Rodriguez HE, Pearce WH, Eskandari MK, Tomita TM. Outcomes in Obese Patients after Mesenteric Revascularization for Chronic Mesenteric Ischemia. Accepted to Annals of Vascular Surgery 24 Sept 2017.

Presentations

Wohlauer M, Jazaeri O, Brown K, Lee A, Hekman K, Magee G, Chaer R, Coleman D. Perspectives and Perceived Needs of the Contemporary Vascular Surgery Trainee: Results of the National APDVS Trainee Survey. Plenary presentation, Vascular Annual Meeting, Boston, MA June 23, 2018.

Hekman KE, Wertheim JA. The Role of Autophagy During Directed Differentiation of Induced Pluripotent Stem Cells to Endothelial Cells: Implications for Vascular Tissue Engineering. Poster presentation, Symposium on Regenerative Engineering, Chicago, IL, May 31, 2018.

Hekman KE, Wertheim JA. The Role of Autophagy During Directed Differentiation of Induced Pluripotent Stem Cells to Endothelial Cells: Implications for Vascular Tissue Engineering. Poster presentation, Gordon Research Conference in Autophagy in Stress, Development and Disease, Barga, Italy, March 18-23, 2018.

Hekman KE. Case Presentation: Hybrid Repair of Chronic Type B Dissection Complicated by Aneurysmal Degeneration. 2nd Annual Clinically Relevant Vascular and Endovascular Surgery (CARVE) Fellows Case Presentation Competition, Vail, CO, February 20, 2018.

Hekman KE. Case Presentation: Open Repair of Aortic Coarctation. 42nd Annual Northwestern Vascular Symposium, Chicago, IL, December 7-9, 2017.

Hekman KE, Hoel AW. Groin Surgical Site Infection Reduction Initiative. Society for Vascular Surgery Quality Improvement Webinar, September 26, 2017.

Hekman KE, Hoel AW. Groin Surgical Site Infection Reduction Initiative. Oral presentation, Mid-America Vascular Surgery Group Fall Meeting, Chicago, IL, September 6, 2017.

Hekman KE, Michel E, Hoel AW. Groin Surgical Site Infection Reduction Initiative. Oral presentation, Vascular Quality Initiative Meeting, San Diego, CA, May 30, 2017.

Hekman KE. Case presentation. 41st Annual Northwestern Vascular Symposium, Chicago, IL, December 8-10, 2016.