Northwestern University Feinberg School of Medicine

Department of Surgery

Faculty Research Awards

NEW AWARDS

Breast Surgery

Clare, Susan “Cytidine Deaminases, Somatic Mutations and Breast Cancer Etiology”     Sponsor: NMF Lynn Sage        Awarded: $50,000

Khan, Seema “Pre-Clinical and Clinical Studies of Breast Cancer Prevention with Transdermal Anti-Progesterone Agent”     Sponsor: Breast Cancer Research Foundation  Awarded: $200,000

Khan, Seema “Pharmacokinetics and intra-mammary distribution of transdermal CDB-4124 vs. oral CDB-4124: a randomized window trial in women undergoing mastectomy”     Sponsor: NCI NIH Contract      Awarded: $832,269

Khan, Seema; Kim, J Julie “Progesterone Signaling and Blockade in Human Breast Tumorigenesis and Prevention”     Sponsor: NCI NIH R01     Awarded: $378,871

CTC

Abecassis, Michael “Integrating Mechanistic Insights from Diverse Models to Prevent CMV Reactivation following Transplantation”     Sponsor: NIAID NIH P01     Awarded: $2,305,939

Abecassis, Michael “Support for Kofi Atiemo”     Sponsor: NIDDKD  NIH T32  Supplemental     Awarded: $84,111

Abecassis, Michael “Effectiveness, Safety and Value of Integrating Molecular Diagnostics into the Post-Transplant Management of Kidney Transplant Recipients - The Next Frontier of Biomarker Research”     Sponsor: NIAID  NIH R34     Awarded: $279,777

Ison, Michael “Protocol IRC002: A Randomized, Open-Label, Phase 2, Multicenter Safety and Exploratory Efficacy Study of Investigational anti-Influenza Immune Plasma for the Treatment of Influenza” Sponsor: NCI (via Social & Scientific Systems, Inc.)                            Awarded: $5,400

Jie, Chunfa “Acute Kidney Injury and Double Negative T Cells”     Sponsor: NIDDKD (via Johns Hopkins University)    Awarded: $8,898

Ladner, Danielle “National Patient Community, Caregiver and Advocacy Group Directed Strategies to Lead Comparative Effectiveness Research for Liver Cirrhosis”     Sponsor: PCORI (via National Network of Public Health Institutes)    Awarded: $15,000

Uzarski, Joseph; Wertheim, Jason “Delineating Determinants of Renal Tubulogenesis in an ECM-based Co-culture Model”  Sponsor: NIDDKDAwarded: $56,894

Wertheim, Jason “Targetable Nanoparticles to Control Inflammation”     Sponsor: NU International Institute for Nanotechnology     Awarded: $100,000

Education

Fryer, Johnathan “Multicenter Study of Operative Autonomy in General Surgery Residents Using SIMPL, the Modified Procedural Autonomy and Supervision System (PASS)”     Sponsor: American Board of Surgery, Inc.         Awarded: $80,000

Plastic Surgery

Dumanian, Greg “Application of Targeted Reinnervation for People with Transradial Amputation”     Sponsor: NICHHD (via RIC)     Awarded: $8,609

Galiano, Robert “Development of Novel Anti-Biofilm Compounds for Treating Chronic Wounds”    Sponsor: NIAID (via Agile Sciences, Inc.)      Awarded: $245,114

Pediatric Surgery

Hunter, Catherine “Defining Bacterial Virulence, Camp and PKA in Necrotizing Enterocolitis”     Sponsor: NIDDKD NIH K08     Awarded: $148,861

Thoracic Surgery

Bharat, Ankit “Pre-Transplant Autoimmunity and Lung Allograft Dysfunction”     Sponsor: Gift of Hope Organ & Tissue Donor Network      Awarded: $50,000

Bharat, Ankit “Pathogenesis of alveolopleural fistulae following lung resection”     Sponsor: American Lung Association     Awarded: $40,000

Bharat, Ankit “High Carbon Dioxide Impairs Lung Repair”     Sponsor: NHLBI NIH K08        Awarded: $130,518

Trauma/Critical Care

Schwulst, Steve “The Role of Innate Immunity in the Traumatic Brain Injury-Induced Immune Suppression Syndrome”     Sponsor: Central Surgical Association Foundation     Awarded: $10,000

Schwulst, Steve “The Role of Innate Immunity in the Traumatic Brain Injury-Induced Immune Suppression Syndrome”     Sponsor: American College of Surgeons                Awarded: $40,000

Schwulst, Steve “The Role of Innate Immunity in the Traumatic Brain Injury-Induced Immune Suppression Syndrome”     Sponsor: NIGMS/NIH K08

Vascular Surgery

Ho, Karen “The Role of the Gut Microbiome in Neointimal Hyperplasia After Arterial Injury”     Sponsor: NMF Dixon     Awarded: $25,000

Eskandari, Mark “Northwestern University Vascular Surgery Fellowship 2015-2016”     Sponsor: Cook Medical     Awarded: $30,000

Eskandari, Mark “Vascular Surgery Fellowship 2015-2016”     Sponsor: Abbott Fund       Awarded: $48,947

Eskandari, Mark “Vascular Surgery Fellowship 2015-2016”    Sponsor: Bard Peripheral Vascular, Inc.     Awarded: $25,000

Kibbe, Melina; Wasserman, Molly “Synthetically Engineered Targeted Gold Nanoparticles for the Prevention of Restenosis Following Vascular Interventions”     Sponsor: American Medical Association Foundation                       Awarded: $2,500

Kibbe, Melina “IPA Agreement for Vera Shively”     Sponsor: Jesse Brown VA Medical Center       Awarded: $50,125

Kibbe, Melina “IPA Agreement for Janet Martinez”     Sponsor: Jesse Brown VA Medical Center       Awarded: $14,985

Kibbe, Melina “IPA Agreement for Qun Jiang”      Sponsor: Jesse Brown VA Medical Center       Awarded: $47,520

NEW CLINICAL TRIALS

CTC

Abecassis, Michael "Proteogenomic Monitoring and Assessment of Kidney Transplant Recipients”     Sponsor: Transplant Genomics, Inc.    Awarded: $667,934

Gallon, Lorenzo “An Observational, Non-Interventional, Multi-Center, Multi-National Study of Patients with Atypical Hemolytic-Uremic Syndrome”    Sponsor: Alexion Pharmaceutics, Inc.      Awarded: $8,769

Leventhal, Joseph “Induction of Donor Specific Tolerance in Recipients of Living Kidney Allografts by Donor Stem Cell Infusion”     Sponsor: Novartis Pharmaceuticals, Co.     Awarded: $1,542,663

Ison, Michael “A Prospective Observational Study for the Long-Term Follow-UP of Subjects Previously Enrolled in Selected Clinical Studies of CMX001”     Sponsor: Chimerix, Inc     Awarded: $28,200

Ison, Michael “A Phase 2B, Randomized, Double-Blind, Placebo-Controlled Multi-Center Study Evaluating Antiviral Effects, Pharmacokinetics, Safety, and Tolerability of GS-5806 in Hospitalized Adults with Respiratory Syncytial Virus (RSV) Infection”     Sponsor: Gilead Sciences, Inc.     Awarded: $71,248

Ison, Michael “GS-US-218-0108: A Phase 2b, Randomized, Double-Blind, Placebo Controlled Multi-Center Study Evaluating Antiviral Effects, Pharmacokinetics, Safety, and Tolerability of GS5806 in Hematopoietic Cell Transplant (HCT) Recipients with Respiratory Syncytial Virus (RSV) Infection of the Upper Respiratory Tract)”     Sponsor: Gilead Sciences, Inc. (via Duke Clinical Research Institute)          Awarded: $53,830

Ison, Michael “GS-US-218-1502: A Phase 2b, Randomized, Double-Blind, Placebo-Controlled Multicenter Study Evaluating Antiviral Effects, Pharmacokinetics, Safety, and Tolerability of GS-5806 in Hematopoietic Cell Transplant (HCT) Recipients with Respiratory Syncytial Virus (RSV) Infection of the Lower Respiratory Tract)”      Sponsor: Gilead Sciences, Inc. (via Duke Clinical Research Institute)          Awarded: $33,144

Levitsky, Josh “A Phase 2, Multicenter, Open-Label Study to Investigate the Safety and Efficacy of Ledipasvir/Sofosbuvir Fixed Dose Combination Administered in Patients Infected with Chronic HCV for Use in the Peri-Operative Liver Transplantation”     Sponsor: Gilead Sciences, Inc. (via ProTrials Research, Inc.)                          Awarded: $181,860

CTU

Ho, Karen “A Phase 3 Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Safety and Efficacy of AMG00001 in Subjects with Critical Limb Ischemia”     Sponsor: AnGes, Inc. (via Quintiles, Inc.)               Awarded: $479,595

Kibbe, Melina “Prot #PLX-PAD 1204-01: A Phase II, Randomized, Double-Blind, Multicenter, Multinational, Placebo-Controlled, Parallel-Groups Study to Evaluate the Safety and Efficacy of Intramuscular Injections of Allogeneic PLX-PAD Cells for the Treatment of Subjects with Intermittent Claudication (IC)”     Sponsor: Pluristem Ltd.      Awarded: $205,925

McCarthy, Patrick “TIARA-1: Early Feasibility Study of the Neovasc Tiara Mitral Transcatheter Heart Valve with the Tiara Transapical Delivery System”     Sponsor: Neovasc Medical Inc.                                  Awarded: $194,805

Plastic Surgery

Galiano, Robert “Clinical Outcomes Associated with Enzymatic Debridement of Diabetic Foot Ulcers for up to 12 weeks with Clostridial Collagenase (Santyl) Ointment”     Sponsor: Smith & Nephew, Inc.                      Awarded: $124,788

Galiano, Robert “A Feasibility Study to Evaluate the SEM Scanner 200 as an Adjunct to Skin Assessment for the Determination of Stage 1 Pressure Ulcers and Suspected Deep Tissue”     Sponsor: Bruin Biometrics, LLC           Awarded: $112,500 

Hong, Seok Jong “Evaluation of promR-29 Treatment Regimen to Prevent Hypertropic Scarring”     Sponsor: miRagen Therapeutics     Awarded: $27,448

NEW AWARDS

Breast Surgery

Clare, Susan “Cytidine Deaminases, Somatic Mutations, and Breast Cancer Etiology”      Sponsor: NMF Lynn Sage Cancer Research Foundation                   Awarded: $50,000

Wang, Jun "Role of HMGCS2-Mediated Ketogenesis in Breast Epithelial-Stromal Interaction"      Sponsor: NMF Lynn Sage Cancer Research Foundation     Awarded: $50,000

CTC

Abecassis, Michael “Mechanisms of MCMV Reactivation in Immunodeficient Transplant Recipients”     Sponsor: NIH                     Awarded: $1,725,000

Leventhal, Joseph “Advancing Transplantation Breakthroughs at Northwestern Medicine: Procurement of Leukapheresis Products from Normal Volunteers and Renal Failure Patients for Immunological Studies”    Sponsor: NMH                  Awarded: $500,000

Stosor, Valentina “Hemophilia Liver Transplantation OLTX Observational Study (HOTS)”     Sponsor: Health Resources and Services Administration (via Hemophilia Center of Western Pennsylvania)            Awarded: $29,250

Wertheim, Jason “Optimization and control of hepatocyte activity via biofuncational modification”     Sponsor: NIDDKD     Awarded: $151,311

Surgical Oncology

Bilimoria, Karl "The FIRST trial"    Sponsor: ACS/ABS      

Halverson, Amy “Continued National Implementation of TeamSTEPPS”     Sponsor: AHRQ (via Health Research and Educational Trust)         Awarded: $36,029

Mahvi, David “Development of an Expandable Radiofrequency ablation Probe for Breast Cancer Treatment” Stage III     Sponsor: NCIIA                 Awarded: $3,000

Thoracic Surgery

Bharat, Ankit "Pre-Transplant Autoimmunity and Lung Allograft Dysfunction"     Sponsor: Gift of Hope Organ & Tissue Donor Network     Awarded: $50,000

Trauma Critical Care

Schwulst, Steven “The Role of Innate Immunity in Traumatic Brain-Injury Induced Immune Suppression”     Sponsor: Shock Society     Awarded: $60,000

Plastic Surgery

Dumanian, Gregory “Operation RESTORE: Developing a Chicago-based, Clinical, Patient-Centered Reconstructive Transplant Program for Severe Tissue Loss Centered at Northwestern Memorial Hospital” Sponsor: NMH             Awarded: $200,000

Vascular Surgery

Ho, Karen "The Role of the Gut Microbiome in Neointimal Hyperplasia After Arterial Injury"     Sponsor: NMF Dixon Young Investigator     Awarded: $25,000

Kibbe, Melina “Development of a Novel Injectable Therapy to Stop Hemorrhage”     Sponsor: Society for Vascular Surgery          Awarded: $3,000

Pearce, William “Vascular Surgery Scientist Training Program-T32”     Sponsor: NHLBI        Awarded: $206,790

NEW CLINICAL TRIALS

CTC

Baker, Talia “A Prospective, Randomized, Double-Blind, Phase II Study to Evaluate the Safety and Efficacy of Topical Thrombin (Human) Grifols as an Adjunct to Hemostasis during Vascular, Parenchymous, Soft Tissue, and Spinal Open Surgeries”     Sponsor: Grifols, Inc. (via Novella Clinical, Inc.)         Awarded: $75,222

Baker, Talia “A 36-Month Multi-Center, Open Label, Randomize,d Comparator Study to Evaluate the Efficacy and Safety of Everolimus Immunosuppression Treatmentin Liver Transplantation for Hepatocellular Carcinoma Exceeding Milan Criteria”     Sponsor: Baylor Research Institute             Awarded: $206,856

Ison, Michael “CR6261CR8020FLZ2001: Multicenter, randomized, double-blind, placebo-controlled study to evaluate the effect of CR8020 and CR6261 in hospitalized patients with influenza A infection”     Sponsor: NAIAD (via. Crucell Holland B.V.)            Awarded: $5,000

Levitsky, Josh “HCV-TARGET: Hepatitis C Therapeutic Registry and Research Network – A Longitudinal, Observational Study”     Sponsor: University of Florida    Awarded: $416,160

Levitsky, Josh “Continuation Funding for the Immune Tolerance Network [ITN030ST (A-WISH)]”     Sponsor: NIAID (via Benaroya Research Institute at Virginia Mason)         Awarded: $11,642

CTU

Eskandari, Mark “BEST-CLI: Trial to Compare Best Endovascular versus Best Surgical Therapy in Patients with Critical Limb Ischemia (BEST)”     Sponsor: NHLBI (via New England Research Institutes, Inc)     Awarded:$110,032

Hoel, Andrew “A Prospective, Multicenter, Single-Blind, Randomized, Controlled Trial Comparing the Lutonix Drug Coated Balloon vs. Standard Balloon Angioplasty for Treatment of Femoropopliteal In-Stent Restenosis”     Sponsor: Lutonix, Inc.       Awarded: $54,300

Plastic Surgery

Galiano, Robert  “A Multi-Center, Prospective, Randomized, Double-Blind, Within-Subject Controlled, Phase 2a Study to Evaluate the Effectiveness and Safety of RXI-109 on the Outcome of Scar Revision Surgery on Transverse Hypertrophic Scars on the Lower Abdomen Resulting from Previous Surgeries in Healthy Adults”     Sponsor: RXi Pharmaceuticals Corp.         Awarded: $197,124

Galiano, Robert “A Retrospective, Multi-center study evaluating the outcomes for INTEGRA Skin Sheet Bilayer or Single Layer Products Used in Complex Lower Extremity Soft Tissue Reconstruction”     Sponsor: Integra LifeSciences Corp.         Awarded: $41,335

Galiano, Robert  “A Phase III Prospective, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability and Efficacy of Curexcell as an Adjunct to Good Ulcer Care Measures in Treating Chronic Venous Leg Ulcers”     Sponsor: MacroCure, LTD. (via Amarex Clinical Research)              Awarded: $181,685

Hong, Seok Jong “The Effect of BRL5990 on Ischemic Wounds”     Sponsor: Bayer Pharma Inc.           Awarded: $133,710 

NEW AWARDS

Breast Surgery

Clare, Susan "Devliery of Nano-Tethered Therapies to Brain Metastases of Primary Breast Cancer Usnig a Cellular Trojan Horse" Sponsor: US Army           Awarded: $141,168

Jeruss, Jacqueline “Impact of CDK Inhibitor Therapy in Triple Negative Breast Cancer”    Sponsor: A Sister’s Hope           Awarded: $25,000

Jeruss, Jacqueline “Measuring Signaling Pathway Dynamics During Tissue Growth in Hydrogels”          Sponsor: NIH          Awarded: $1,478,906

Jeruss, Jacqueline “Pilot: Evaluation of Physician and Patient-Level Factory, Including Fertility Concerns, that Affect Adherence to Tamoxifen for Young Women Diagnosed with Breast Cancer”       Sponsor: NICHHD                 Awarded: $77,250

Jeruss, Jacqueline “Synergistic Action of Carboplatin/Eribulin in Combination with CDK Inhibitor Therapy for the Treatment of Triple Negative Cancer”           Sponsor: SSO     Awarded: $50,000

Jeruss, Jacqueline “Impact of Pin1 and CDK Inhibition in Triple Negative Breast Cancer Migration”       Sponsor: NMF Lynn Sage                     Awarded: $50,000

Khan, Seema “The Humanized Mouse Mammary Fat Pad for Testing Breast Cancer Prevention Drugs”    Sponsor: NMF   Awarded: $50,000

Khan, Seema “Acceptability of skin application of preventive medications for breast cancer: a pilot study of women's views on acceptability of skin application of preventive medications for cancer”      Sponsor: NMH                  Awarded: $9,031

Khan, Seema “Pre-clinical and clinical studies of breast cancer prevention with transdermal anti-progesterone agents”      Sponsor: Breast Cancer Research Foundation         Awarded: $240,000

Khan, Seema “Hormone Receptor-Specific Cancer Risk Biomarkers in Benign Breast” Sponsor: Komen Breast Cancer Foundation         Awarded: $227,121

Khan, Seema “Protein Expression of RANKL in Benign Breast Tissues During the Menstrual Cycle and in Pregnancy-Associated Breast Tumor Tissues”           Sponsor: Amgen, Inc.     Awarded:$191,924

Khan, Seema “Pre-clinical and Clinical Studies of Breast Cancer Prevention with Transdermal Anti-progesterone Agents”                Sponsor: Breast Cancer Research Foundation     Awarded: $240,000

Khan, Seema “Presurgical Phase IIB Trial of Oral CDB-4124 vs. Placebo in Women with Stage I-III Primary Breast Cancer”     Sponsor: Repros        Awarded: $298,782

CTC

Abecassis, Michael “Utilization of a Large, Multi-organizational Database for Clinical Monitoring and Prognostications: Donor and Recipient Impact of Multi-Drug Resistant Organisms in Transplant”  Sponsor: Gift of Hope Organ & Tissue Donor Network              Awarded: $30,000

Leventhal, Joseph “Expansion of Facilitating Cells to Enhance Graft Tolerance”     Sponsor: NMF        Awarded: $30,000

Levitsky, Josh “A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Efficacy, Safety and Pharmacokinetics of Rifaximin 550mg in Subjects with Severe Hepatic Impairment and Over Hepatic Encephalopathy”     Sponsor: Salix Pharmaceuticals, Inc.                        Awarded: $154,755 for study, $40,370 for additional PK Sub-study

Levitsky, Josh “Delayed Chimerism Induction in Liver Transplants with Bioengineered Marrow Cells”      Sponsor: NMF             Awarded: $50,000

Levitsky, Josh  “Open-Label, Single Arm, Phase 2 Study to Evaluate the Safety and Efficacy of the Combination of ABT-450/ritonavir/ABT-267 (ABT-450/r/ABT-267) and ABT-333 Coadministered with Ribavirin (RBV) in Adult Liver Transplant Recipients with Genotype 1 Hepatitis C Virus (HCV) Infection”     Sponsor: AbbVie Inc.                                      Awarded: $321,650

Shah, Ramille “Multifunctional Printed Scaffolds for Enhancing Hepatocyte Viability and Function”    Sponsor: NIDDKD             Awarded: $130,325

Wertheim, Jason “A Micro-sized Bioscaffold Derived from Kidney Extracellular Matrix Tissue to Evaluate Renal Progenitor Cell Differentiation for Tissue Engineering Applications”   Sponsor: National Kidney Foundation of Illinois                  Awarded: $60,000

Wertheim, Jason “Development of a Small caliber Vascular Graft Using a Tissue Engineering Strategy”    Sponsor: NMF Dixon Translational Research Grant           Awarded: $50,000

Wertheim, Jason “Development of a Humanized Liver in a Rodent Model of Auxiliary Liver Transplantation”       Sponsor: Society for Surgery of the Alimentary Tract, Inc.             Awarded: $100,000

Wertheim, Jason “Development of a Bioartificial Kidney”     Sponsor: ASTS Foundation     Awarded: $50,000

Wertheim, Jason “A Micro-sized Bioscaffold Derived from Kidney Extracellular Matrix Tissue To Evaluate Renal Progenitor Cell Differentiation for Tissue Engineering Applications”     Sponsor: National Kidney Foundation of Illinois          Awarded:$120,000

Zhang, Zheng Jenny “Pilot Study Using a Mouse Model of Kidney Transplantation”          Sponsor: University of Pittsburgh             Awarded: $4,611

GI Surgery

Hungness, Eric; Teitelbaum, Ezra “Multidisciplinary Curriculum for Laparoscopic Common Bile Duct Exploration”     Sponsor: NMF Baum     Awarded: $42,271

Hungness, Eric “General Surgery Residency Training & Pediatric Surgery Fellowship”     Sponsor: Covidien       Awarded: $70,000

Surgical Oncology

Bilimoria, Karl  “Illinois Surgical Quality Improvement Collaborative (ISQIC)”    Sponsor: Blue Cross, Blue Shield of Illinois            Awarded: $18,200,000

Bilimoria, Karl “Engaging Patients and Hospitals to Expand Public Reporting in Surgery”   Sponsor: AHRQ/NIH      Awarded: $938,011

Bilimoria, Karl “Multidisciplinary Sarcoma Care: Trends, Outcomes and Ensuring Quality”       Sponsor: DeBoer Family Sarcoma Research Grant              Awarded: $25,000

Bilimoria, Karl “Sentinel Lymph Node Positivity Rates for Breast Cancer and Melanoma: an Opportunity to Improve Quality and Enhance the NCCN Guidelines”     Sponsor: NCCN             Awarded: $150,000

Bilimoria, Karl “New Approach to Measuring and Improving Surgical Cancer Quality”     Sponsor: ACS, Illinois             Awarded: $250,000

Mahvi, David “Development of an Expandable Radiofrequency Ablation Probe for Breast Cancer Treatment - Stage 1”        Sponsor: NCIIA           Awarded: $5,000

Mahvi, David “Development of an Expandable Radiofrequency Ablation Probe for Breast Cancer Treatment - Stage 2”        Sponsor: NCIIA           Awarded: $19,369

Mahvi, David  “The NUvention Fellowship”      Sponsor: Cook Medical Incorporated            Awarded: $15,000

Plastic Surgery

Dumanian, Gregory “Targeted reinnervation as a means to treat neuromas associated with major limb amputation”                Sponsor:  Dept of Defense           Amount: $2,459,187 

Galiano, Robert “ In-vivo functional muscle regeneration utilizing an implantable modular bioreactor”    Sponsor: Dept of Defense via subaward (consortium) from Wake Forest University Health Sciences       Amount:$1,000,000

Galiano, Robert “Antibacterial Surgical Sealants for Enhanced Healing of Biofilm-Infected Wounds” Sponsor: Dixon Translational Research Grants Initiative Awarded: $50,000

Mustoe, Thomas “Locally applied statins to reduce scarring”        Sponsor: Dept of Defense via subaward (consortium) from Wake Forest University Health Sciences        Amount: $800,000

Mustoe, Thomas  “Rho Kinase Inhibitor AR-12286 as a Potential Anti-Scarring Agent in Rabbit Ear Model”         Sponsor: Aeire Pharmaceuticals, Inc.      Awarded: $50,490

Thoracic Surgery

Bharat, Ankit “John H. Gibbon Jr. Research Scholarship Award (2014-2016)”   Sponsor: AAST     Awarded: $160,000

Vascular Surgery

Eskandari, Mark “Vascular Surgery Fellowship Program Grant 2013-2014”     Sponsor: Boston Scientific Foundation      Awarded: $20,000

Eskandari, Mark “Abbott Vascular Surgery Fellowship Grant 2013-2014”     Sponsor: Abbott Fund     Awarded: $35,888.60

Kibbe, Melina; Stupp, Samuel “Novel Vehicles for Targeted Cardiovascular Repair”     Sponsor: NHLBI     Awarded: $4,314,867

Kibbe, Melina; Ameer, Guillermo “Preclinical Investigation of a Bioengineered Vascular Graft”     Sponsor: NIBIB   Awarded: $1,715,625

Kibbe, Melina; Gregory, Elaine “Improving Graft Patency: A Novel L-Ascorbic Acid ePTFE Modification”     Sponsor: NHLBI        Awarded: $59,432

Kibbe, Melina “The Modulation of SCA-1 Stem Cells by Nitric Oxide in a Diabetic Mouse Model”     Sponsor: American Medical Association Foundation             Awarded: $2,500

Kibbe, Melina “Influence of Endothelial Microparticles on Nitric Oxide’s Ability to Inhibit Neointimal Hyperplasia”     Sponsor: American Medical Association Foundation             Awarded: $2,500

Kibbe, Melina “Development of a Targeted Therapy to Prevent Restenosis Following Cardiovascular Interventions”     Sponsor: AHA, Midwest Affiliate                                            Awarded: $98,476

Kibbe, Melina “A Novel Therapy to Treat Atheroscleorsis”   Sponsor: Dixon Translational Research Grants Initiative                Awarded: $50,000

Kibbe, Melina; Albaghdadi, Mazen “Evaluation of the Efficacy of a Liquid Cast Drug-Eluting Biodegradable Stent”     Sponsor: NHLBI                     Awarded: $172,386

Kibbe, Melina; Jill Streams “The Modulation of SCA-1 Stem Cells by Nitric Oxide in a Diabetic Mouse Model”     Sponsor: American Medical Association Foundation     Awarded: $2,500

Kibbe, Melina; Zach Emond “Influence of Endothelial Microparticles on Nitric Oxide’s Ability to Inhibit Neointimal Hyperplasia”     Sponsor: American Medical Association Foundation     Awarded: $2,500

Kibbe Melina; Stupp, Sam; Moriera, Ed “Development of a Targeted Therapy to Prevent Restenosis following Cardiovascular Interventions”     Sponsor: AHA Midwest, Inc.       Awarded: $98,476

NEW CLINICAL TRIALS

Breast Surgery

Khan, Seema “Development of Anti-Progesterone Drugs for Breast Cancer”    Sponsor: Repros Therapeutics, Inc.                          Awarded: $96,956

CTC

Gallon, Lorenzo  “Evaluating Nulojix Long Term Safety in Transplant, EnLiST Registry”     Sponsor: Bristol-Myers Squibb     Awarded: $40,400

Leventhal, Joseph “Stem Cells to Improve Organ Transplantation”   Sponsor: Novartis              Awarded: $12,000,000

Leventhal, Joseph “Delayed Tolerance in Recipients of Living Kidney Allograts by Donor Stem Cell Infusion”    Sponsor: Kentucky Science and Technology Corp. and Regenerex LLC     Awarded: $97,182

Levitsky, Josh  “The Effects of Everolimus with and without Tacrolimus and Mycophenolic Acid on Donor-Specific TRegs in the TReg-MLR”        Sponsor: Novartis Pharmaceutical Corp.                Awarded: $219,161

CTU

Eskandari, Mark “A Randomised, Double-blind, Parallel group, Multicentre Phase IIIB study to Compare Ticagrelor with Clopidogrel Treatment on the Risk of Cardiovascular Death, Myocardial Infarction and Ischaemic Stoke in Patients with Established Peripheral Artery Disease (EUCLID) - Examining Use of tiCagreLor In paD”     Sponsor: Astra Zeneca LP                                         Awarded: $139,255

Eskandari, Mark “’GREAT’ Global Registry for Endovascular Aortic Treatment Outcomes Evaluation”     Sponsor: W. L. Gore and Associates                         Awarded:  $73,642

Eskandari, Mark “A Multicenter, Open Label, Prospective, Non-Randomized Study of the Incraft Stent Graft System in Subjects with Abdominal Aortic Aneurysms”       Sponsor: Cordis Corporation       Awarded: $138,550

Eskandari, Mark “Evaluation of the GORE TIRGRIS Vascular Stent in the Treatment of Atherosclerotic Lesion of the Superficial Femoral and Proximal Popliteal Arteries”     Sponsor: W. L. Gore and Associates                         Awarded: $100,199

Grady, Kathleen “Pediatric Heart Transplantation: Transitioning to Adult Care”    Sponsor: NHLBI (via Ann & Robert H. Lurie Children’s Hospital of Chicago)             Awarded: $55,456

Hoel, Andrew “Developing a Survey Instrument for Patients with Abdominal Aortic Aneurysm (AAA)”       Sponsor: Dartmouth College                       Awarded: $4,000

Malaisrie, S.C. Chris “Neomend Progel: A Prospective, Randomized Study to Compare Progel Vascular Sealant to Gelfoam Plus as an Adjunct for the Control of Bleeding in Subjects Undergoing Thoracic Aortic Surgery”     Sponsor: Neomend, Inc.                               Awarded: $136,357

McCarthy, Patrick “A Phase I Randomized, Double-Blind, Placebo Controlled Dose Escalation Study to Evaluate the Safety and Efficacy of JVS-100 Administered by Needle-free Dermal Injection to Cohorts of Adults  Receiving Surgical Sternotomy Incisions”     Sponsor: SironRX Therapeutics, Inc.                       Awarded: $69,840

McCarthy, Patrick “Multi-Center Experience with the Rapid Deployment Edwards Intuity Valve System for Aortic Valve Replacement (Transform Trial)" Sponsor: Edwards Lifesciences Corp.      Awarded: $602,580

McCarthy, Patrick  “AtriCure Synergy Ablation Lesions for Non-Paroxysmal Forms of Atrial Fibrillation Treatment During Concomitant On-Pump Endo-Epicardial Cardiac Surgery”    Sponsor: AtriCure, Inc.          Awarded: $41,500

McGee, Edwin “A Multi Center Post Approval Study Providing Continued Evaluation and Follow-up on Patients who Received a HeartWare Ventricular Assist System During IDE Trials for the Treatment of Advanced Heart Failure”     Sponsor: HeartWare, Inc.             Awarded: $31,792

McGee, Edwin “Clinical Outcomes Assessment of the MitraClip Percutaneous Therapy for High Surgical Risk Patients (The COAPT Trial): A Clinical Evaluation of the Safety”                Sponsor: Evalve, Inc.      Awarded: $463,626

McGee, Edwin “OPTIVAD Registry: Application of OptiVol Technology in the Evaluation of the Continuous Flow Left ventricle Assist Device (cf-LVAD) Population”    Sponsor: Medtronic Inc. (via AHS Hospital Corp)                Awarded: $12,595

McGee, Edwin  “A Prospective, Randomized, Controlled, Unblinded, Multi-Center Clinical Trial to Evaluate the HeartWare Ventricular Assist Device System for Destination Therapy of Advanced Heart Failure”    Sponsor: Heartware, Inc.              Awarded: $42,450

Plastic Surgery

Galiano, Robert “A Prospective, Randomized, Multi-Center Trial Evaluating the Effectiveness of the VAC Ultra Negative Pressure Wound Therapy System with VAC VeraFlo Dressing System in Operatively Debrided Wounds”    Sponsor: KCI USA, Inc                    Awarded: $314,920

Galiano, Robert “A Phase 2, Randomized, Double-Blind, Within-Subject, Placebo-Controlled Study to Evaluate the Efficacy and Safety of PF-06473871 in Reducing Hypertrophic Skin Scarring”     Sponsor: Pharmaceutical Research Assoc. (via Pfizer)  Awarded : $106,784

Galiano, Robert “A Prospective, Randomized, Multi-Center Trial Evaluating the Effectiveness of the V.A.C.Ulta™ Negative Pressure Wound Therapy System with V.A.C. VeraFlo™ Dressing System in Operatively Debrided Wounds”     Sponsor: KCI USA, Inc.     Awarded: $370,420

Galiano, Robert “A Double-Blind, Multi-center, Randomized, Sham-Controlled, Parallel Group Comparison of the dermaPACE® (Pulsed Acoustic Cellular Expression) Device in Conjunction with Standard of Care Versus Standard of Care Alone in the Treatment of Diabetic Foot Ulcers”     Sponsor: SANUWAVE, Inc.           Awarded: $120,350

Galiano, Robert “A Phase 3 Randomized, Double Blind, Vehicle Controlled Study Investigating the Safety and Efficacy of HP802-247 in the Treatment of Venous Leg Ulcers >12cm2 to ≤ 36cm2”     Sponsor: Healthpoint, Ltd.           Awarded: $143,690

Kapp-Simon, Kathleen “Craniofacial Microsomia: Longitudinal Outcomes in Children pre-Kindergarten (CLOCK)”     Sponsor: Seattle Children’s         Awarded:  $299,306

Kim, John “A Prospective, Multi-Center, Randomized, Open Label Controlled Trial Using a Dissolved Oxygen Enriched Dressing in Nipple-Sparing Mastectomy”     Sponsor: Kimberley-Clark Corp.                 Awarded: $47,168

Kim, John “Outcomes Associated with the use of (Flex-HD9r) Pliable™ Human Acellular Dermis, in Assisted Tissue Expander Breast Reconstruction: A Multi-Center Prospective Study”     Sponsor: Musculoskeletal Transplant Foundation, Inc.          Awarded: $435,500

NEW AWARDS

Breast Surgery

Jeruss, Jacqueline “ACS Jacobson Award”     Sponsor: ACS     Awarded: $15,000

Jeruss, Jacqueline; Tarasewicz, Elizabeth  “The Dichotomous Role of TGF-beta/Smad3 Signaling in Breast Cancer” Sponsor: CBC Scholars      Awarded: $5,000

Jeruss, Jacqueline “CDK Inhibition and Restoration of Smad3 Signaling in Aggressive Breast Cancer Subtypes”  Sponsor: Central Surgical Association Foundation  Awarded: $10,000

Khan, Seema “Nipple Aspiration Fluid Yielders and Non-Yielders: Genetic and Tumor Characteristics”  Sponsor: Avon Products Foundation      Awarded: $10,000

Khan, Seema “Pre-Clinical Studies of Breast Cancer Prevention with Transdermal Anti-progesterone Agents” Sponsor: Breast Cancer Research Foundation       Awarded: $150,000

Khan, Seema “Progesterone Antagonist for the Prevention of Breast Cancer” Sponsor: NMF      Awarded: $35,000

 

CTC

Abecassis, Michael “Genomics for Transplantation: Discovery and Biomarkers”   Sponsor: NIAID/Scripps Research Institute          Awarded: $292,315

Abecassis, Michael “Initiating a Research Program in Bioartificial Organs” Sponsor: NMH   Amount: $416,811

Abecassis, Michael “Transplant Surgery Scientist Training Program”         Sponsor: NIDDKD             Awarded: $1,117,530

Abecassis, Michael; Hummel, Mary “Role of Innate Immunity and Injury in Transplant-Induced Reactivation of MCMV” Sponsor: NIAID    Awarded: $193,125

Ameer, Guillermo, Wertheim, Jason “Conferring Thromboresistance to Decellularized Vascular Grants” Sponsor: Chemistry of Life Processes Institute      Awarded: $50,000

Friedewald, John “An Observational Study to Assess the Prevalence of a Tolerance Signature in Renal Transplant Recipients” Sponsor: NIAID/UCSF    Awarded: $151, 391

Friedewald, John “Addressing Geographical Disparities in Transplant Organ Accessibility Across United States”   Sponsor: NSF       Awarded: $98,424

Ison, Michael “Achieving Consensus on High Risk Donors to Improve Access to Organ Transplantation” Sponsor: Agency for Healthcare Research & Quality   Awarded: $49,944

Ison, Michael  “IRC002”  Sponsor: National Institute of Allergy and Infectious Diseases       Awarded: $68,500

Ladner, Daniela “Geographic Inequity in Kidney Transplant Allocation: Model Feasible Solutions” Sponsor: AHRQ        Awarded: $30,000

Ladner, Daniela “Addressing Geographical Disparities in Transplant Organ Accessibility Across United States” Sponsor: NSF         Awarded: $98,424

Ladner, Daniela “A2ALL-Patient Safety System Improvements in Living Donor Liver Transplantation” Sponsor: NIDDK            Awarded: $1,700,000

Leventhal, Joseph “Induction of Donor Tolerance in Renal Transplants” Sponsor: NIDDKD/Regenerex, LLC  Awarded: $396,401

Leventhal, Joseph; Miller, William “Isolation, Characterization and Expansion of Human Facilitating Cells from Deceased Donor Bone Marrow”    Sponsor: Baxter Healthcare         Awarded: $90,000

Wertheim, Jason “ 2012 ASTS-OptumHealth Presidential Student Mentor Grant”              Sponsor: ASTS Foundation             Awarded: $3,500

Wertheim, Jason “Construction of Engineered Organs Using Human Organ-Specific Progenitor Cells”  Sponsor: Dixon Translational Research Grant      Awarded: $25,000

Wertheim, Jason “Liver Tissue Engineering”  Sponsor: 2012 American Association for The Study of Liver Diseases/American Liver Foundation Scholar Award                Awarded: $225,000

Wertheim, Jason  “Liver Tissue Engineering and Regeneration”                 Sponsor: American Liver Foundation       Awarded: $75,000

GI Surgery

Hungness, Eric “Evaluation of a Simulation-Based Master Learning Curriculum for Laparoscopic Common Bile Duct Exploration”    Sponsor: NMF      Awarded: $44,072

 

Plastic Surgery

Dumanian, Gregory “Development of Advanced Prosthetic Systems” Sponsor: U.S. Army Medical Research & Material Command    Awarded: $73,049

Mustoe, Thomas; Hong, Seok Jong; Galiano, Robert “Stabilized Hemoglobin Wound Healing Development”  Sponsor: U.S. Army Medical Research & Material Command                 Awarded: $350,000

Mustoe, Thomas “Medical Device Innovation Program (MDIP) of the Division of Plastic Surgery of Northwestern University”  Sponsor: National Collegiate Inventors & Innovators Alliance                      Awarded: $15,000

 

Surgical Oncology

Bilimoria, Karl “Multidisciplinary Sarcoma Care: Trends, Outcomes, and Ensuring Quality” Sponsor: NMF Awarded: $50,000

Grippo, Paul “N-3 Fatty Acid-Induced Akt Suppression: Chemoprevention for Pancreatic Neoplasia”       Sponsor: NIH/NCI         Awarded: $333,835

Halverson, Amy “Disparities: Chicago Colon Cancer Patterns of Care Study” Sponsor: National Institute on Minority Health/UIC   Awarded: $35,878

McGee, Michael; McCarthy, Daniel “The Use of Interactive Technology to Enhance Patient Engagement and Education at the Point of Care” Sponsor: National Network of Libraries of Medicine   Awarded: $3,830

 

Trauma and Critical Care

Schwulst, Steven “Prevention of Traumatic Brain Injury-Induced Immune Cell Apoptosis” Sponsor: AAST              Awarded: $50,000

Swaroop, Mamta “Development of a Prospective, Observational Traumatic Brain Injury Registry” Sponsor: NMF     Awarded: $14,000

 

Vascular Surgery

Eskandari, Mark “Vascular Surgery Fellowship Program 2012-2013”          Sponsor: Boston Scientific Foundation, Inc.        Awarded: $25,000

Eskandari, Mark “Illinois Surgical Quality Improvement Collaboration Conference” Sponsor: ACS  Awarded: $4,995

Kibbe, Melina; Gregory, Elaine “Postdoc Fellowship for Elaine Gregory in Support of L-Ascorbis Acid-Poly(diol-citrate): An Innovative Approach to Improve Vascular Surgery Outcomes”   Sponsor: American Heart Association Midwest Affiliate                Awarded: $105,884

Yao, James S.T;  Nicole Higashiyama “Initiative to Fight Hepatitis B”          Sponsor: Alumnae Northwestern             Awarded: $2,923

NEW CLINICAL TRIALS

 

CTC

Levitsky, Josh “A 2-Part, Open-Label Study of Telaprevir in Combination with Peginterferon Alpha-2a(Pegasys) and Ribavirin (Copegus) in Subjects Chronically Infected with Genotype 1 Hepatitis C Virus Following Liver Transplantation”  Sponsor: Vertex Pharmaceuticals Incorporated Awarded: $179,081

 

CTU

Grady, Kathleen “Develop a Mechanical Circulatory Support JRQOL Instrument” Sponsor: AHA  Awarded: $142,537

Grady, Kathleen  “Mechanical Circulatory Support: Development & Use of Quality of Life Instruments” Sponsor: American Heart Association Midwest Affiliate         Awarded: $71,310

Kibbe, Melina “A Phase IIa Randomized Double-Blind, Placebo Controlled Dose Escalation Study to Evaluate the Safety and Efficacy of JVS-100 Administered by Direct Intramuscular Injection to Cohorts of Adults with Critical Limb Ischemia”                Sponsor: Jeuventas Therapeutics, Inc.   Awarded: $488,641

Pearce, William “A Phase 3 Randomized, Single Blind, Controlled Trial of Topical Fibrocaps in Intraoperative Surgical Hemostatsis (FINISH-3)”   Sponsor: Profibrix, Inc. / Novella Clinical, Inc. Awarded: $93,138

Rodriguez, Heron “Prot-P5634: Durability Iliac”  Sponsor: Coviden Ltd.    Awarded: $36,250

 

Plastic Surgery

Galiano, Robert “A Phase 2, Open-Label Study to Provide Revision of Scars Resulting from Surgery in Prior Studies of EXC001”  Sponsor: Excaliard Pharmaceuticals, Inc.             Awarded: $14,577

Galiano, Robert “A Phase 3, Randomized, Double-Blind, Vehicle Controlled Study Investigating the Safety and Efficacy of HP802-247 in the Treatment of Venous Leg Ulcers”          Sponsor: Healthpoint, Ltd.           Awarded: $225,252

Galiano, Robert  “A Prospective, Randomized, Intra-patient, Comparative, Open Multi-Center Study to Evaluate the Efficacy of a Single-Use Negative Pressure Wound Therapy (NPWT) System (PICO) on the Prevention of Postsurgical Incision Healing”  Sponsor: Smith & Nephew, Inc.                 Awarded: $110,655

Galiano, Robert “IN-BALANCE VLU: Inflammation, Bacteria & Angiogenesis Effects in Launching Venous Leg Ulcer Healing”                                                    Sponsor: Celleration  Awarded: $415,614

Galiano, Robert “At Home Evaluation of Two Pneumatic Compression Devices in the Treatment of Lower Extremity Lymphedema (ACE: At home Compression Evaluation)”  Sponsor: Tactile Systems Tech.                Awarded: $155,920

Galiano, Robert; Hong, Seok Jong ; Mustoe, Thomas “BIOMASK: The Use of an In-Vivo Bioreactor as a Biologic Platform for the Guided Self-Contained Fabrication of a Composite Facial Regenerate”  Sponsor: U.S. Army Medical Research & Material Command     Awarded: $905,507

Hong, Seok Jong “The Effect of Hyaluron-Based Hydrogel on the Survival of Adipocytes Graft”  Sponsor: BioTime, Inc.        Awarded: $24,660

Mustoe, Thomas “The Effect of Antimicrobial Dressing on Bacterial-Biofilm Infected Wounds” Sponsor: ConvaTec      Awarded: $54,469